Sansepolcro's 14th-century duomo contains an Ascension by Perugino, a Resurrection by Raffaellino del Colle and a polyptych by Niccolò di Segna that is thought to have influenced Piero's Resurrection . Left of the main altar is the striking Il Volto Santo (Sacred Face), a wooden crucifix with a wide-eyed Christ in a blue gown that dates to the 9th century, and – nearby – a beautiful ceramic tabernacle (unfortunately badly chipped) by Andrea della Robbia.
Leaving the cathedral, turn right onto Piazza Garabaldi to admire the 16 medallions by Andrea della Robbia on the facade of Palazzo Preterio .