The Chiesa di San Domenico lies Off Via Roma. It was built in 1640 following the design of architect Andrea Cirincione; the façade was added in 1726 after the buildings that once occupied the square were demolished to give the church some space.
The church has been the place where Italian VIPs have been buried since the Middle Ages; among the tombs and cenotaphs of notable Sicilians, you'll find the names of parliamentarian Ruggero Settimo, painter Pietro Novelli, and the former Italian prime minister Francesco Crispi.