At the southern end of Santiponce, this exquisite, two-church former monastery was founded in 1301 by Guzmán El Bueno (hero of the 1294 battle at Tarifa). Over the centuries it hosted a succession of different religious orders, including the hermetic Hieronymite monks who embellished the Patio de Evangelistas with particularly striking 15th-century murals of saints and Mudéjar-style floral and geometric patterns. It was here that the Bible was first translated into Castilian (1569).
Among the monastery's impressive Spanish art collection is a wonderful altarpiece by 17th-century Sevillan sculptor Juan Martínez Montañés.