The Centro de Arte Reina Sofia - or Reina Sofia Museum - is Madrid's premier modern art gallery featuring mostly works by Spanish artists. Amongst them is Guernica, a political statement on the Spanish Civil War by Picasso, as well as a room devoted to Joan Miró's paintings and a collection of about 20 Dalí pieces.
One's adventure through the gallery begins with a ride up the glass elevator, which provides excellent views of the plaza and buildings below. The second floor houses the permanent collection, broken up into about 10 rooms while the top floor is taken up with works from artists of the 1980's as well as those of international artists.
Don't forget to stop at the gift shop on your way out to grab a print or postcard of your favorite piece!