The architects behind the Marquette Building made natural light and ventilation vital components. While that’s nice, the most impressive features are the sculptured panels and mosaics that recall the exploits of French explorer Jacques Marquette; look for them above the entrance and in the lobby (where there’s also a free little exhibit on Chicago School architecture).
The MacArthur Foundation, bestowers of the ballyhooed 'genius grants' each year, own the building and also have an exhibit just off the lobby.