The protected area at San Lorenzo is best explored with a guide, easily arranged at the Centro El Tucán, a community learning and visitors center that lies on the edge of the reserve. Guides generally charge US$60 per group for a two-hour hike, though longer and more difficult treks can also be arranged. El Tucán also has an excellent documentation center on the flora and fauna, human ecology and history.
The visitors center is located in the village of Achiote, 13km north of Escobal, on the edge of the reserve. Since there is no public transportation to the town and there are few taxis in the area, Achiote is best accessed by private vehicle.