Most access to the park is from the north and west; access from the south and east is difficult. If starting from Macas, make your goal the alpine lakes, including the scenic Lagunas de Tinguichaca or the popular Sardina Yaca lagoons, which are teeming with wildlife.
The volcano itself is inaccessible from here. Buses from Macas go to 9 de Octubre and San Vicente, a good starting point for most hikes. The small settlement of Purshi is the official entrance. It’s best to enter with a guide as trails are faint and require acute navigation and machete skills. Trips here are not for the uninitiated outdoors person.